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Volume : 34 Issue : 3 Year : 2019



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Comparison of Antithrombin III and Pentoxifylline Treatments in Gram Negative Sepsis Patients Developing DIC [Medeniyet Med J]
Medeniyet Med J. 2019; 34(3): 233-238 | DOI: 10.5222/MMJ.2019.05935  

Comparison of Antithrombin III and Pentoxifylline Treatments in Gram Negative Sepsis Patients Developing DIC

Mesure Gül Nihan Özden1, Guniz Koksal2, Hüseyin Öz3
1I Medeniyet University Göztepe Education Research Hospital Anesthesiology and Reanimation Clinic / Istanbul
2IU Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department / Istanbul
3I Medipol University Anesthesiology and Reanimation Department / Istanbul

INTRODUCTION: The aim of this study was to evaluate the effects of Antithrombin III (AT III) and Pentoxifylline treatments on the gram negative septic patients with DIC.
MATERIAL AND METHODS: When plasma AT III activity was lower than 80%, AT group of patients were treated with AT III 90-120 IU/kg/day in 6 hours for 6 days and PTX group of patients were treated with 1.5 mg/kg/h of Pentoxifylline in 6 hours in 6 days. Fibrinogen, FDP, D-dimer, complete blood count, AT III activity, coagulation tests of patients were recorded daily. DIC scores were calculated and recorded daily also.
RESULTS: The coagulation tests, AT III activity and FDP started coming normal value on the second day of treatment with both treatments (p<0.05). D-Dimer decreased on the second day of treatment with pentoxifylline (p<0.001) and fourth day of AT III treatment (p<0.05). Fibrinogen became decreasing on the second day of pentoxifylline treatment (p<0.05) and on the last day of AT III treatment (p<0.001). DIC scores started to decrease on the last day of treatment with AT III treatment (p<0.001) and on the third day of treatment with pentoxifylline (p<0.05).
CONCLUSIONS: Both ATIII and pentoxifylline treatments had similar positive effects on the patients with DIC developing gram negative sepsis and AT levels started to rise early and reached normal values with both treatments.
KEYWORDS: Gram negative sepsis, Disseminated Intravascular Coagulation, Antithrombin, Pentoxifylline.

Keywords: Gram negative sepsis, Disseminated Intravascular Coagulation, Antithrombin, Pentoxifylline.


DİK Gelişen Gram Negatif Sepsis Hastalarında Antitrombin III ve Pentoksifilin Tedavilerinin Karşılaştırılması

Mesure Gül Nihan Özden1, Guniz Koksal2, Hüseyin Öz3
1İ Medeniyet Üniversitesi Göztepe Eğitim Araştırma Hastanesi Anesteziyoloji ve Reanimasyon Kliniği / İstanbul
2İÜ Cerrahpaşa Tıp Anesteziyoloji ve Reanimasyon Anabilimdalı / İstanbul
3İ Medipol Üniversitesi Anesteziyoloji ve Reanimasyon Anabilimdalı / İstanbul

GİRİŞ: Çalışmamızda Disemine İntravasküler Koagülasyon (DİK) gelişen Gram negatif sepsis hastalarında Antitrombin III (AT III) ve Pentoksifilin tedavilerinin etkinliğini karşılaştırmayı amaçladık.
METOD: DiK gelişen gram negative sepsis hastalarında AT III aktivitesinin % 80’in altına düştüğü günü takipeden 6 gün hastaların bir kısmına 90-20 IU/kg/gün 6 saat olacak şekilde AT III, diğer kısmına 1.5mg/kg/saat 6 saat olucak şekilde pentoksifilin tedavisi uygulandı. Fibrinojen, FDP, D-Dimer, tam kansayımı, ATIII aktivitesive DİK skorlarına bakıldı.
BULGULAR: Koagülasyon testleri, AT III aktivitesi ve FDP her iki tedavi ile tedavinin 2. gününden itibaren iyileşmeye başladı (p<0.05). D-Dimer Pentoksifilin tedavisiyle tedavinin 2. Gününden (p<0.001), AT III tedavisiyle 4. gününden itibaren (p<0.05) düşmeye başladı. Fibrinojen düzeyleri Pentoksifilin tedavisinin 2. Günü (p<0.05), AT III tedavisinin son gününde (p<0.001) düştü. DiK skorları Pentoksifilin tedavisiyle tedavinin 3. Gününde (p<0.05) AT III tedavisiyle tedavinin son gününde (p<0.001) düştü.
SONUÇ: olarak DİK gelişen gram negatif sepsis hastalarında AT III ve Pentoksifilin tedavilerinin her ikisininde koagülasyon testleri, Fibrinojen, FDP, D-Dimer, AT III aktivitesive ve DİK skorları üzerine olumlu etkisi vardır.
Anahtar Kelimeler: Gram negatif sepsis, Dissemine İntravasküler Koagulasyon, Antitrombin, Pentoksifilin.

Anahtar Kelimeler: Gram negatif sepsis, Dissemine İntravasküler Koagulasyon, Antitrombin, Pentoksifilin.


Mesure Gül Nihan Özden, Guniz Koksal, Hüseyin Öz. Comparison of Antithrombin III and Pentoxifylline Treatments in Gram Negative Sepsis Patients Developing DIC. Medeniyet Med J. 2019; 34(3): 233-238

Corresponding Author: Mesure Gül Nihan Özden, Türkiye


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